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Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.


Journal article


Microbes and infection

Publication Date





567 - 574


Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.


Thymus Gland, CD4-Positive T-Lymphocytes, Humans, Gastrointestinal Diseases, Inflammatory Bowel Diseases, Cell Differentiation, Substrate Specificity, Homeostasis