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Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.

Type

Journal article

Journal

Microbes Infect

Publication Date

04/2002

Volume

4

Pages

567 - 574

Keywords

CD4-Positive T-Lymphocytes, Cell Differentiation, Gastrointestinal Diseases, Homeostasis, Humans, Inflammatory Bowel Diseases, Substrate Specificity, Thymus Gland