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Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.


Journal article


Microbes infect

Publication Date





567 - 574


CD4-Positive T-Lymphocytes, Cell Differentiation, Gastrointestinal Diseases, Homeostasis, Humans, Inflammatory Bowel Diseases, Substrate Specificity, Thymus Gland