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Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.

Original publication

DOI

10.1016/s1286-4579(02)01574-5

Type

Journal article

Journal

Microbes and infection

Publication Date

04/2002

Volume

4

Pages

567 - 574

Addresses

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Keywords

Thymus Gland, CD4-Positive T-Lymphocytes, Humans, Gastrointestinal Diseases, Inflammatory Bowel Diseases, Cell Differentiation, Substrate Specificity, Homeostasis