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Bone resorption is required for skeletal modelling during bone growth and for mineral homeostasis and bone remodelling throughout life. Osteoclasts are multinucleated cells that are uniquely specialised to carry out this physiological bone resorption. As osteolysis is a feature of most diseases of bone and joint, osteoclasts also play a role in pathological bone resorption, the extent of which is a function of the cellular and molecular mechanisms that govern their formation and function.

Original publication

DOI

10.1007/s00256-011-1180-9

Type

Journal article

Journal

Skeletal radiology

Publication Date

09/2011

Volume

40

Pages

1137 - 1140

Addresses

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK. nick.athanasou@ndorms.ox.ac.uk

Keywords

Osteoclasts, Humans, Bone Resorption, Bone Remodeling