Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24.
Savulescu C., Prats-Uribe A., Brolin K., Uusküla A., Bergin C., Fleming C., Murri R., Zvirbulis V., Zavadska D., Gaio V., Popescu CP., Hrisca R., Cisneros M., Latorre-Millán M., Lohur L., McGrath J., Ferguson L., De Gaetano Donati K., Abolina I., Gravele D., Machado A., Florescu S-A., Lazar M., Subirats P., Clusa Cuesta L., Sui J., Kenny C., Santangelo R., Krievins D., Barzdina EA., Valadas Henriques C., Kosa AG., Pohrib S-M., Muñoz-Almagro C., Milagro A., Bacci S., Nardone A., VEBIS HCW VE study group None., Collaborators in VEBIS HCW study group None.
COVID-19 vaccination recommendations include healthcare workers (HCWs). We measured COVID-19 vaccine effectiveness (CVE) of the autumn 2023 dose against laboratory-confirmed SARS-CoV-2 infection in a prospective cohort study of 1,305 HCWs from 13 European hospitals. Overall CVE was 22% (95% CI: -17 to 48), 49% (95% CI: -8 to 76) before and -11% (95% CI: -84 to 34) after the start of BA.2.86/JN.1 predominant circulation. Autumn 2023 COVID-19 vaccination led to a moderate-to-low reduction in SARS-CoV-2 infection incidence in HCWs. Monitoring of CVE is crucial for COVID-19 prevention.