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Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17 CD161(++)CD8αβ(+) T cells exist in cord blood, from which a prominent MAIT cell (TCR Vα7.2(+)) population emerges post-natally. During this expansion, CD8αα T cells appear exclusively within a CD161(++)CD8(+)/MAIT subset, sharing cytokine production, chemokine-receptor expression, TCR-usage, and transcriptional profiles with their CD161(++)CD8αβ(+) counterparts. Our data demonstrate the origin and differentiation pathway of MAIT-cells from a naive type-17 precommitted CD161(++)CD8(+) T-cell pool and the distinct phenotype and function of CD8αα cells in man.

Original publication

DOI

10.1182/blood-2011-05-353789

Type

Journal article

Journal

Blood

Publication Date

01/2012

Volume

119

Pages

422 - 433

Addresses

Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, United Kingdom.

Keywords

T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Fetal Blood, Humans, Receptors, Antigen, T-Cell, Protein Isoforms, RNA, Messenger, Antigens, CD8, Cytokines, Fluorescent Antibody Technique, Blotting, Western, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Cell Differentiation, Antigen Presentation, Immunity, Mucosal, Adult, Infant, Newborn, Th17 Cells, Real-Time Polymerase Chain Reaction, Biomarkers