Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Feldmann M., Andreakos E., Smith C., Bondeson J., Yoshimura S., Kiriakidis S., Monaco C., Gasparini C., Sacre S., Lundberg A., Paleolog E., Horwood NJ., Brennan FM., Foxwell BM.
There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.