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There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Original publication




Journal article


Annals of the rheumatic diseases

Publication Date



61 Suppl 2


ii13 - ii18


Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK.


Synovial Membrane, Dendritic Cells, Humans, Adenoviridae, Arthritis, Rheumatoid, NF-kappa B, Lymphocyte Culture Test, Mixed, Cell Culture Techniques, Immunity, Cellular, Antigen Presentation, Genetic Vectors, I-kappa B Proteins