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The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine synthesis. In almost a decade since this discovery, a great deal has been learned about the role of the p38 pathway in the post-transcriptional regulation of pro-inflammatory gene expression. However, important questions remain to be answered concerning the specificity and mechanism or mechanisms of action of p38. This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38.

Original publication




Journal article


FEBS letters

Publication Date





37 - 44


Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK.


Animals, Humans, Inflammation, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Signal Transduction, MAP Kinase Signaling System, Protein Processing, Post-Translational, Models, Biological