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Plasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine.To confirm that demyelinating diseases (DD) cause increased urinary FLCs.Urinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC).Subjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p<0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI.Urinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity.

Original publication

DOI

10.1016/j.jneuroim.2010.01.012

Type

Journal article

Journal

Journal of neuroimmunology

Publication Date

03/2010

Volume

220

Pages

99 - 103

Addresses

Neuroimmunology Unit, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, United Kingdom. ruth.dobson@qmul.ac.uk

Keywords

Humans, Acquired Immunodeficiency Syndrome, Arthritis, Rheumatoid, Multiple Sclerosis, Uveitis, Posterior, Immunoglobulins, Predictive Value of Tests, Up-Regulation, Adult, Middle Aged, Female, Immunoglobulin Light Chains, Male, Biomarkers