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Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

Original publication




Journal article


Cellular and molecular life sciences : CMLS

Publication Date





3175 - 3199


Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK.


Myocardium, Myocytes, Smooth Muscle, Stem Cells, Animals, Humans, Mice, Rats, Neoplasms, Myocardial Infarction, Vascular Diseases, Neovascularization, Pathologic, Tenascin, Wound Healing, Gene Expression Regulation, Atherosclerosis, Neoplastic Stem Cells