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Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

Original publication

DOI

10.1007/s00018-011-0783-6

Type

Journal article

Journal

Cell Mol Life Sci

Publication Date

10/2011

Volume

68

Pages

3175 - 3199

Keywords

Animals, Atherosclerosis, Gene Expression Regulation, Humans, Mice, Myocardial Infarction, Myocardium, Myocytes, Smooth Muscle, Neoplasms, Neoplastic Stem Cells, Neovascularization, Pathologic, Rats, Stem Cells, Tenascin, Vascular Diseases, Wound Healing