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Metalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system, fibrosis, and infection, as well as others. This unit provides an overview of metalloproteases, including their classification, catalytic mechanisms, structures, substrate specificities, and common inhibitors.

Original publication

DOI

10.1002/0471140864.ps2104s24

Type

Journal article

Journal

Current protocols in protein science

Publication Date

08/2001

Volume

Chapter 21

Pages

Unit - 21.4

Addresses

Imperial College School of Medicine, London, United Kingdom.

Keywords

Animals, Metalloproteases, Protease Inhibitors, Substrate Specificity, Catalysis