Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To investigate the patterns of myocardial involvement in the presence of self-limiting and sustained systemic inflammation, using MRI. METHODS: Ninety-four subjects, with a clinical diagnosis of myocarditis (n = 36), RA (n = 24) and apparently healthy subjects (n = 34, control group), underwent standardized cardiac MRI protocol for the assessment of global and regional morphology and systolic function using balanced steady-state free precession sequences, T2-weighted images and late gadolinium enhancement (LGE) studies. RESULTS: The three groups were well matched for age, gender and cardiovascular risk factors. The RA group showed markedly increased end-diastolic volumes and reduced ejection fraction (P < 0.05). Antero/inferolateral wall thickness was greater in the myocarditis group and reduced in RA, associated with reduced radial and longitudinal thickening (P < 0.01), and markedly raised T2-oedema ratio and global LGE scores (P < 0.05). CONCLUSIONS: Our results may signify the phenotypic features of myocardial plasticity and deformation in response to self-limiting and sustained inflammatory injury.

Original publication




Journal article


Rheumatology (oxford)

Publication Date





528 - 535


Adult, Arthritis, Rheumatoid, Biomarkers, C-Reactive Protein, Female, Humans, Inflammation Mediators, Magnetic Resonance Imaging, Male, Middle Aged, Myocarditis, Phenotype, Stroke Volume, Ventricular Function, Left, Ventricular Remodeling