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The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Proatherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgroups of patients with inflammatory diseases. Common molecular pathways shared by atherosclerosis and inflammatory disease may be involved. In this review we map the key determinants of the increased incidence of cardiovascular disease in patients with inflammatory diseases at each step of the atherogenesis.

Original publication

DOI

10.1186/ar2631

Type

Journal article

Journal

Arthritis Res Ther

Publication Date

2009

Volume

11

Keywords

Animals, Arthritis, Rheumatoid, Atherosclerosis, Humans, Lupus Erythematosus, Systemic