Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Woon ECY.; Tumber A.; Kawamura A.; Hillringhaus L.; Ge W.; Rose NR.; Ma JHY.; Chan MC.; Walport LJ.; Che KH.; Ng SS.; Marsden BD.; Oppermann U.; McDonough MA.; Schofield CJ.

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Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Woon ECY., Tumber A., Kawamura A., Hillringhaus L., Ge W., Rose NR., Ma JHY., Chan MC., Walport LJ., Che KH., Ng SS., Marsden BD., Oppermann U., McDonough MA., Schofield CJ.

Original publication

DOI

10.1002/anie.201107833

Type

Journal article

Journal

Angew chem int ed engl

Publication Date

13/02/2012

Volume

Pages

1631 - 1634

Keywords

Binding Sites, Cross-Linking Reagents, Humans, Jumonji Domain-Containing Histone Demethylases, Ketoglutaric Acids, Models, Molecular, Molecular Structure, Structure-Activity Relationship, Substrate Specificity