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Deposition of immunoglobulins in the skin of patients with lupus erythematosus (LE), demonstrable as a linear band 'lupus band' at the basement membrane zone (BMZ) by direct immunofluorescence, was first described in 1963. Four decades after the discovery of the lupus band, a basic question regarding the origin of immunoglobulins of the lupus band is still unanswered. Is the lupus band just a manifestation of polyclonal B-cell activation commonly seen in systemic LE (SLE)? The distribution of IgG subclasses deposited in the skin of patients with SLE was identified using immunohistochemistry. The relative restriction of IgG of the lupus band to the IgG3 subclass demonstrated in this study provides evidence against polyclonal B-cell activation as the only cause of the lupus band and suggests disease-specific alteration in subclass switching.

Original publication

DOI

10.1111/j.1365-2230.2004.01520.x

Type

Journal article

Journal

Clinical and experimental dermatology

Publication Date

05/2004

Volume

29

Pages

288 - 292

Addresses

Department of Dermatology, Oxford Radcliffe Hospital, Oxford, UK. AbdelazizHM@aol.com.uk

Keywords

Basement Membrane, B-Lymphocytes, Skin, Humans, Lupus Erythematosus, Systemic, alpha-Macroglobulins, Immunoglobulin G, Fluorescent Antibody Technique, Direct, Lymphocyte Activation, Immunoglobulin Class Switching