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We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.

Original publication

DOI

10.1002/ana.20051

Type

Journal article

Journal

Ann neurol

Publication Date

03/2004

Volume

55

Pages

430 - 434

Keywords

Adolescent, Adult, Aged, Case-Control Studies, Cross-Sectional Studies, Cytochrome P-450 CYP2D6, Environmental Exposure, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Occupational Exposure, Parkinson Disease, Pesticides, Polymerase Chain Reaction, Polymorphism, Genetic, Prevalence