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T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach to the direct visualisation of antigen-specific T cells. As a result, our perspective of how T cells respond to both viruses and other antigens in vivo has been greatly enhanced.

Original publication

DOI

10.1186/ar315

Type

Journal article

Journal

Arthritis research

Publication Date

01/2001

Volume

3

Pages

265 - 269

Addresses

MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK. mysun@worf.molbiol.ox.ac.uk

Keywords

CD8-Positive T-Lymphocytes, T-Lymphocytes, Cytotoxic, Humans, Autoimmune Diseases, Histocompatibility Antigens Class I, Immunotherapy, Flow Cytometry, Dimerization