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Interest in microbubble ultrasound contrast agents as therapeutic and quantitative imaging tools has increased the need for accurate modeling of their behavior. Experiments have shown that some bubbles shrink significantly over the course of a single pulse but that the bubbles may eventually reach a stable size after many insonations. Here, it is shown from dimensional arguments that diffusion phenomena are negligible on the time scales that characterize a typical ultrasound pulse. Subsequently, a new model describing both a lipid-shedding mechanism and a nonlinear surface viscosity is developed and shown to provide a more accurate description of the observed experimental behavior.

Original publication

DOI

10.1121/1.3630219

Type

Journal article

Journal

The Journal of the Acoustical Society of America

Publication Date

10/2011

Volume

130

Pages

EL180 - EL185

Addresses

Department of Mathematics, University College London, London, United Kingdom. jpobrien@math.ucl.ac.uk

Keywords

Lipids, Contrast Media, Surface-Active Agents, Linear Models, Microbubbles, Diffusion, Surface Properties, Viscosity, Nonlinear Dynamics, Ultrasonics, Pressure, Computer Simulation