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Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

Original publication

DOI

10.1126/scitranslmed.3004184

Type

Journal article

Journal

Sci transl med

Publication Date

06/06/2012

Volume

4

Keywords

Gastrointestinal Tract, Health, Humans, Inflammatory Bowel Diseases, Metagenome