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We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection in 20 other patients known to have antibodies to U1RNP or in 36 British and West German patients with idiopathic adult polymyositis. In addition the serum from 20 anti-HTLV-1 positive patients did not contain antinuclear antibodies or antibodies to U1RNP. We conclude that rheumatological disease is associated with HTLV-1 through geographical rather than aetiological means.

Type

Journal article

Journal

British journal of rheumatology

Publication Date

04/1991

Volume

30

Pages

141 - 143

Addresses

Department of Medicine, Hammersmith Hospital and Royal Postgraduate Medical School, London.

Keywords

Humans, HTLV-I Infections, Mixed Connective Tissue Disease, Autoimmune Diseases, Serologic Tests, Adult, Middle Aged, West Indies, Great Britain, Female