Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A fixed microelectrode device for cell stimulation has been designed and fabricated using micro-electro-mechanical systems (MEMS) technology. Dielectrophoretic forces obtained from non-uniform electric fields were used for manipulating and positioning osteoblasts. The experiments show that the osteoblasts experience positive dielectrophoresis (p-DEP) when suspended in iso-osmotic culture medium and exposed to AC fields at 5 MHz frequency. Negative dielectrophoresis (n-DEP) is obtained at 0.1 MHz. The viability of osteoblasts under dielectrophoresis has been investigated. The viability values for cells exposed to DEP are nearly three times higher than the control values, indicating that dielectrophoresis may have an anabolic effect on osteoblasts.

Type

Journal article

Journal

Biomedical microdevices

Publication Date

12/2006

Volume

8

Pages

353 - 359

Addresses

Optical and Semiconductor Devices Group, EEE Dept., Imperial College, Exhibition Road, London, SW7 2AZ, UK. h.zou@imperial.ac.uk

Keywords

Cell Line, Tumor, Osteoblasts, Humans, Electrophoresis, Microchip, Cell Culture Techniques, Microelectrodes, Cell Survival