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The 5-year relative survival of adults diagnosed with acute myeloid leukaemia (AML) was less than 10% during the 1970s and 1980s in England. This population-based study estimated the 5-year relative survival and 'cure' for 48 380 adult patients diagnosed with AML in England during 1971-2006. Relative survival and cure mixture models were used to produce estimates of 5-year relative survival and the percentage 'cured'. 'Cure' was defined as the proportion of a group of survivors for whom there is no excess mortality compared with the general population. The 5-year relative survival and the percentage 'cured' increased for patients aged under 70 years at diagnosis during 1971-2006, but advancing age was associated with poorer outcome. During the study period a dramatic increase in 5-year relative survival occurred in those aged 15-24 years, from 7% to 53%. The percentage 'cured' was less than 10% for all ages in 1975, but increased to 45% for those aged 15-24 years in 2000. Cure could not be estimated for patients over 70 years, because survival was consistently low (<5%). The long-term outcome of patients with AML has improved substantially, particularly in younger patients. The potential exists for further increasing levels of 'cure'.

Original publication

DOI

10.1111/bjh.12425

Type

Journal article

Journal

British journal of haematology

Publication Date

08/2013

Volume

162

Pages

509 - 516

Addresses

Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK. anjali.shah@npeu.ox.ac.uk

Keywords

Humans, Treatment Outcome, Remission Induction, Registries, Mortality, Survival Rate, Retrospective Studies, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, England, Female, Male, Leukemia, Myeloid, Acute, Young Adult