Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Rearrangements to the T-cell receptor (TcR) beta and gamma gene loci were studied in T cells derived from the thyroid glands of a patient with Hashimoto's (HT) and another with Graves' (GD) autoimmune thyroiditis. The cells studied were freshly isolated mononuclear cells, T-cell lines grown in the presence of anti-CD3 and IL-2 and T-cell clones. Numerous different rearrangements to the constant regions of TcR beta and TcR gamma and in the variable gene region of TcR beta were observed. These findings indicate that the T-cell response in autoimmune thyroiditis is multiclonal and may have implications for the epitopes recognized by autoreactive T cells and for the mechanisms of the disease.

Original publication

DOI

10.1016/0896-8411(89)90103-0

Type

Journal article

Journal

Journal of autoimmunity

Publication Date

02/1989

Volume

2

Pages

1 - 13

Addresses

Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK.

Keywords

Thyroid Gland, T-Lymphocytes, Clone Cells, Humans, Thyroiditis, Autoimmune, Autoimmune Diseases, Receptors, Antigen, T-Cell, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Autoantigens, Epitopes, Lymphocyte Activation, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Adult, Middle Aged, Female, Graves Disease