Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

Original publication

DOI

10.1084/jem.20050783

Type

Journal article

Journal

The Journal of experimental medicine

Publication Date

13/03/2006

Volume

203

Pages

505 - 511

Addresses

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

Keywords

Dendritic Cells, CD4-Positive T-Lymphocytes, Animals, Mice, Transgenic, Mice, Autoantigens, Microscopy, Confocal, Cell Adhesion, Cell Communication, Cell Movement, Antigen Presentation, T-Lymphocytes, Regulatory