Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

CD2-associated protein (CD2AP) is an 80-kilodalton protein that is critical for stabilizing contacts between T cells and antigen-presenting cells. In CD2AP-deficient mice, immune function was compromised, but the mice died at 6 to 7 weeks of age from renal failure. In the kidney, CD2AP was expressed primarily in glomerular epithelial cells. Knockout mice exhibited defects in epithelial cell foot processes, accompanied by mesangial cell hyperplasia and extracellular matrix deposition. Supporting a role for CD2AP in the specialized cell junction known as the slit diaphragm, CD2AP associated with nephrin, the primary component of the slit diaphragm.

Original publication

DOI

10.1126/science.286.5438.312

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

10/1999

Volume

286

Pages

312 - 315

Addresses

Center for Immunology and Department of Pathology, Washington University, Saint Louis, MO 63110, USA.

Keywords

Kidney Glomerulus, Glomerular Mesangium, Basement Membrane, T-Lymphocytes, Intercellular Junctions, Epithelial Cells, Animals, Mice, Knockout, Mice, Nephrotic Syndrome, Adaptor Proteins, Signal Transducing, Proteins, Cytoskeletal Proteins, Membrane Proteins, Recombinant Fusion Proteins, Extracellular Matrix Proteins, Microscopy, Electron, Lymphocyte Activation