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Intercellular adhesion molecule 1 (ICAM-1) is a 90 kd inducible surface glycoprotein that promotes adhesion in immunological and inflammatory reactions. ICAM-1 is a ligand of lymphocyte function-associated antigen-1 (LFA-1), an alpha beta complex that is a member of the integrin family of cell-cell and cell-matrix receptors. ICAM-1 is encoded by an inducible 3.3 kb mRNA. The amino acid sequence specifies an integral membrane protein with an extracellular domain of 453 residues containing five immunoglobulin-like domains. Highest homology is found with neural cell adhesion molecule (NCAM) and myelin-associated glycoprotein (MAG), which also contain five Ig-like domains. NCAM and MAG are nervous system adhesion molecules, but unlike ICAM-1, NCAM is homophilic. The ICAM-1 and LFA-1 interaction is heterophilic and unusual in that it is between members of the immunoglobulin and intergrin families. Unlike other integrin ligands, ICAM-1 does not contain an RGD sequence.

Original publication

DOI

10.1016/0092-8674(88)90434-5

Type

Journal article

Journal

Cell

Publication Date

03/1988

Volume

52

Pages

925 - 933

Addresses

Laboratory of Membrane Immunochemistry, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

Keywords

Lymphocytes, Humans, Leukemia, Hairy Cell, Immunoglobulins, Membrane Glycoproteins, Cell Adhesion Molecules, RNA, Messenger, Antigens, Surface, Cloning, Molecular, Genes, Immunoglobulin, Amino Acid Sequence, Base Sequence, Genes, Molecular Sequence Data