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Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.

Original publication

DOI

10.4161/19336918.2014.987587

Type

Journal article

Journal

Cell adhesion & migration

Publication Date

01/2015

Volume

9

Pages

48 - 82

Addresses

a Nuffield Department of Orthopaedics; Rheumatology and Musculoskeletal Sciences ; Kennedy Institute of Rheumatology; University of Oxford ; Oxford , UK.

Keywords

Brain, Animals, Humans, Tenascin, Signal Transduction, Gene Expression Regulation, Protein Processing, Post-Translational, Gene Regulatory Networks