Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Reference Point Indentation (RPI) has been proposed as a new clinical tool to aid the diagnosis of Osteoporosis. This study has examined the performance of the tool within entire femurs to improve the understanding of the mechanical properties of bone and also to guide future RPI testing to optimize repeatability of results obtained using the technique. Human, bovine, porcine and rat femurs were indented along three longitudinal axes: anterior and posterior: medial and lateral as well as around the circumference of the femoral head and neck. Cortical and subchondral bone thickness was measured using CT and radiography. The study shows that in some samples, bone is too thin to support the high loads applied with the technique and in these cases, RPI values are highly influenced by thickness. The technique will be useful in the mid-shaft region where cortical thickness is greatest, providing previously established guidelines are followed to optimize measurement repeatability, including performing multiple measurements per sample and investigating multiple samples. The study has also provided evidence that RPI values vary significantly with test site, hence mechanical properties should not be inferred from RPI findings alone away from the test site, even within the same bone. In conclusion, RPI appears to be a useful tool for scientific investigation; however further work is required to examine the feasibility of using RPI for assessing differences between healthy and diseased bone in a clinical setting.

Original publication

DOI

10.1016/j.jmbbm.2015.02.004

Type

Journal article

Journal

Journal of the mechanical behavior of biomedical materials

Publication Date

06/2015

Volume

46

Pages

292 - 304

Addresses

Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK. Electronic address: L.V.Coutts@soton.ac.uk.

Keywords

OStEO Group, Femur, Animals, Cattle, Humans, Rats, Osteoporosis, Materials Testing, Aged, Aged, 80 and over, Middle Aged, Female, Male, X-Ray Microtomography, Mechanical Phenomena