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Macrophages are ubiquitous phagocytes that can constitute up to 15% of the cellular content of tissues. These heterogeneous cells of the innate immune system perform important functions during health and disease. Equipped with receptors for the T helper cell cytokines INF-γ and IL-4, macrophages undergo specific activation programs during Th1 or Th2 immune responses. These activation profiles, termed classical (M1) or alternative (M2) activation respectively, are further tuned by the presence and recognition of microbial-associated molecular patterns, other cytokines, lipids, and even adhesion to the substratum. The activation of macrophages also relies on the maturation background of the cells, elicitation of complicated intracellular signalling cascades, and the crosstalk between the different signalling elements. Of interest, not all genes participating in the activation-related signalling cascades are equally important for the elicitation of functional profiles and a regulator gene hierarchy is emerging for the different types of activation. In this issue of the European Journal of Immunology, two papers add to our understanding of how cellular kinases and phosphatases, related to the PI3K pathway, regulate M1 or M2 activation programmes in macrophages.

Original publication

DOI

10.1002/eji.201141670

Type

Journal article

Journal

European journal of immunology

Publication Date

06/2011

Volume

41

Pages

1531 - 1534

Addresses

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. fernando.martinezestrada@path.ox.ac.uk

Keywords

Macrophages, Animals, Mice, Knockout, Mice, Phosphoric Monoester Hydrolases, MAP Kinase Kinase Kinases, Proto-Oncogene Proteins, Signal Transduction, Macrophage Activation, Gene Expression Regulation, Nitric Oxide Synthase Type II, Phosphatidylinositol 3-Kinases, Th1-Th2 Balance, Inositol Polyphosphate 5-Phosphatases