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To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria.Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups.Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups.This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.

Original publication

DOI

10.1093/rheumatology/41.10.1183

Type

Journal article

Journal

Rheumatology (Oxford, England)

Publication Date

10/2002

Volume

41

Pages

1183 - 1189

Addresses

Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Keywords

British Paediatric Rheumatology Study Group, Humans, Genetic Predisposition to Disease, HLA-B27 Antigen, HLA-D Antigens, HLA-DP Antigens, HLA-DQ Antigens, HLA-DR Antigens, Risk Factors, Haplotypes, Phenotype, Adolescent, Child, Child, Preschool, Infant, Female, Male, HLA-DRB1 Chains, HLA-DP beta-Chains, Arthritis, Juvenile, United Kingdom