Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Invariant natural killer T (iNKT) cells promote immune responses to various pathogens, but exactly how iNKT cells control antiviral responses is unclear. Here, we showed that iNKT cells induced tissue-specific antiviral effects in mice infected by lymphocytic choriomeningitis virus (LCMV). Indeed, iNKT cells inhibited viral replication in the pancreas and liver but not in the spleen. In the pancreas, iNKT cells expressed the OX40 molecule and promoted type I interferon (IFN) production by plasmacytoid dendritic cells (pDCs) through OX40-OX40 ligand interaction. Subsequently, this iNKT cell-pDC cooperation attenuated the antiviral adaptive immune response in the pancreas but not in the spleen. The dampening of pancreatic anti-LCMV CD8(+) T cell response prevented tissue damage in transgenic mice expressing LCMV protein in islet beta cells. Thus, this study identifies pDCs as an essential partner of iNKT cells for mounting an efficient, nondeleterious antiviral response in peripheral tissue.

Original publication

DOI

10.1016/j.immuni.2008.12.017

Type

Journal article

Journal

Immunity

Publication Date

20/02/2009

Volume

30

Pages

289 - 299

Keywords

Animals, CD8-Positive T-Lymphocytes, Dendritic Cells, Diabetes Mellitus, Liver, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Mice, Natural Killer T-Cells, OX40 Ligand, Organ Specificity, Pancreas, Receptors, OX40, Signal Transduction, Spleen, Virus Replication