Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To assess the associations of HLA class II antigens with systemic lupus erythematosus (SLE) in black South Africans. METHODS: HLA-DRB1 genotype frequencies assigned by polymerase chain reaction (PCR) amplification and sequence specific oligonucleotide probes were compared between 49 black SLE patients from Baragwanath Hospital and 87 ethnically matched controls. HLA-DQA1 and -DQB1 genotypes were also assigned in 45 of the SLE patients and 74 controls by PCR using sequence specific primers. RESULTS: HLA-DRB1*02 was increased in the patients compared with controls (odds ratio = 3.67; 95% confidence interval = 1.49 to 9.02; p < 0.005). HLA-DQB1*0201 was not associated with development of the disease itself, but was associated with the presence of Ro antibodies (p = 0.01). HLA-DRB1*03 was less strongly linked to DQB1*02 in this population than in white populations and was not associated with SLE. CONCLUSIONS: In black South Africans there is evidence for a locus on DR2 haplotypes contributing to SLE. Another gene, possibly HLA-DQB1*02, not linked to DR2 is involved in the subset of patients exhibiting Ro antibodies.

Original publication

DOI

10.1136/ard.54.8.678

Type

Journal article

Journal

Annals of the rheumatic diseases

Publication Date

08/1995

Volume

54

Pages

678 - 680

Addresses

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

Keywords

Humans, Lupus Erythematosus, Systemic, Disease Susceptibility, Antibodies, Antinuclear, Histocompatibility Antigens Class II, HLA-DQ Antigens, HLA-DR Antigens, HLA-DR2 Antigen, Histocompatibility Testing, Genotype, Adolescent, Adult, Middle Aged, African Continental Ancestry Group, South Africa, Female, Male