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Poly(epsilon-caprolactone) (PCL) with a bone-like apatite layer bound to its surface could be useful as a scaffold for tissue engineering applications. In the present study, the surface of PCL was treated with aqueous NaOH to introduce carboxylate groups onto the surface. The NaOH-treated material was subsequently dipped in aqueous CaCl(2) and K(2)HPO(4).3H(2)O alternately three times to deposit apatite nuclei on the surface. The surface-modified material successfully formed a dense and uniform bone-like surface apatite layer after incubation for 24 h in simulated body fluid with ion concentrations approximately equal to those of human blood plasma.

Original publication

DOI

10.1016/j.biomaterials.2004.07.048

Type

Journal article

Journal

Biomaterials

Publication Date

05/2005

Volume

26

Pages

2407 - 2413

Keywords

Absorbable Implants, Apatites, Biomimetic Materials, Body Fluids, Bone Substitutes, Materials Testing, Polyesters, Porosity, Surface Properties, Tissue Engineering