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Over recent decades, the perception of osteoporosis has changed from that of an inevitable consequence of ageing, to that of a well characterised and treatable chronic non-communicable disease, with major impacts on individuals, healthcare systems and societies. Characterisation of its pathophysiology from the hierarchical structure of bone and the role of its cell population, development of effective strategies for the identification of those most appropriate for treatment, and an increasing armamentarium of efficacious pharmacological therapies, have underpinned this evolution. Despite this marked progress, individuals who experience a fragility fracture remain under-treated in many areas of the world, and there is substantial need for investment both in secondary and primary prevention globally. In this brief article, we give an overview of the pathogenesis of osteoporosis, and summarise current and future approaches to its assessment and treatment.

Original publication

DOI

10.7861/clinmedicine.15-6-s92

Type

Journal article

Journal

Clinical medicine (London, England)

Publication Date

12/2015

Volume

15 Suppl 6

Pages

s92 - s96

Addresses

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

Keywords

Humans, Osteoporosis, Risk Factors