Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.

Original publication

DOI

10.1016/j.immuni.2010.05.007

Type

Journal article

Journal

Immunity

Publication Date

05/2010

Volume

32

Pages

593 - 604

Addresses

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. siamon.gordon@path.ox.ac.uk

Keywords

Macrophages, Animals, Humans, Neoplasms, Receptors, Interleukin, Cytokines, Signal Transduction, Macrophage Activation, Models, Biological