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Hibernoma is a benign adipose tumour that contains foetal brown fat cells. We report a case of hibernoma arising in the left ischium of a 65-year-old female with a past history of ovarian carcinoma. The patient presented with a relatively short history of left sacral/hip pain. Radiologically, the lesion, which was large (5 cm) and sclerotic, had been stable for a number of years. Histologically, it was composed mainly of plump cells with foamy, multivacuolated cytoplasm. These cells showed no reaction for epithelial, melanoma or leucocyte markers but expressed FABP4/aP2 and S100, indicating that they were brown fat cells. There was no mitotic activity or nuclear pleomorphism and the lesion was diagnosed as a benign intraosseous hibernoma (IOH). IOH is a recently identified benign adipocytic lesion that presents typically as a sclerotic bone lesion. It has characteristic morphological and immunophenotypic features and should be regarded as a discrete primary bone tumour that needs to be distinguished from metastatic carcinoma/melanoma, chondrosarcoma and metabolic storage diseases containing numerous foamy macrophages.

Original publication

DOI

10.1007/s00256-016-2460-1

Type

Journal article

Journal

Skeletal radiology

Publication Date

11/2016

Volume

45

Pages

1565 - 1569

Addresses

Department of Radiology, Nuffield Orthopaedic Centre, Oxford, UK.

Keywords

Humans, Lipoma, Bone Neoplasms, Rare Diseases, Diagnosis, Differential, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Female