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The scientific literature contains evidence suggesting that women who have been treated for breast cancer may, as a result of their diagnosis, increase their phyto-oestrogen (PE) intake. In the present paper, we describe the creation of a dietary analysis database (based on Dietplan6) for the determination of dietary intakes of specific PE (daidzein, genistein, glycitein, formononetin, biochanin A, coumestrol, matairesinol and secoisolariciresinol), in a group of women previously diagnosed and treated for postmenopausal breast cancer. The design of the database, data evaluation criteria, literature data entry for 551 foods and primary analysis by LC–MS/MS of an additional thirty-four foods for which there were no published data are described. The dietary intake of 316 women previously treated for postmenopausal breast cancer informed the identification of potential food and beverage sources of PE and the bespoke dietary analysis database was created to, ultimately, quantify their PE intake. In order that PE exposure could be comprehensively described, fifty-four of the 316 subjects completed a 24 h urine collection, and their urinary excretion results allowed for the description of exposure to include those identified as ‘equol producers’.

Original publication

DOI

10.1017/s0007114512004394

Type

Journal article

Journal

The British journal of nutrition

Publication Date

06/2013

Volume

109

Pages

2261 - 2268

Addresses

Emergency Response and Recovery Programme, Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, UK. don.clarke@fera.gsi.gov.uk

Keywords

Humans, Breast Neoplasms, Isoflavones, Phytoestrogens, Statistics, Nonparametric, Food Analysis, Postmenopause, Aged, Middle Aged, Diet Records, Female, Databases as Topic, Equol