Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Autophagy is increasingly recognized for its active role in development and differentiation. In particular, its role in the differentiation of hematopoietic cells has been extensively studied, likely because blood cells are accessible, easy to identify and purify, and their progenitor tree is well defined. This review aims to discuss the mechanisms by which autophagy impacts on differentiation, using hematopoietic cell types as examples. Autophagy's roles include the remodeling during terminal differentiation, the maintenance of a long-lived cell type, and the regulation of the balance between self-renewal and quiescence in stem-like cells. We discuss and compare the mechanistic roles of autophagy, such as prevention of apoptosis, supply of energy metabolites and metabolic adaption, and selective degradation of organelles and of regulatory factors.

Original publication




Journal article


Febs j

Publication Date





1008 - 1020


autophagy, differentiation, hematopoiesis, hematopoietic stem cell, lineage commitment, Animals, Apoptosis, Autophagy, Autophagy-Related Protein 5, Autophagy-Related Protein 7, B-Lymphocytes, Cell Differentiation, Energy Metabolism, Gene Expression Regulation, Hematopoietic Stem Cells, Homeostasis, Humans, Immunologic Memory, Killer Cells, Natural, T-Lymphocytes, Thymus Gland