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Autophagy is increasingly recognized for its active role in development and differentiation. In particular, its role in the differentiation of hematopoietic cells has been extensively studied, likely because blood cells are accessible, easy to identify and purify, and their progenitor tree is well defined. This review aims to discuss the mechanisms by which autophagy impacts on differentiation, using hematopoietic cell types as examples. Autophagy's roles include the remodeling during terminal differentiation, the maintenance of a long-lived cell type, and the regulation of the balance between self-renewal and quiescence in stem-like cells. We discuss and compare the mechanistic roles of autophagy, such as prevention of apoptosis, supply of energy metabolites and metabolic adaption, and selective degradation of organelles and of regulatory factors.

Original publication

DOI

10.1111/febs.13962

Type

Journal article

Journal

The FEBS journal

Publication Date

04/2017

Volume

284

Pages

1008 - 1020

Addresses

Kennedy Institute of Rheumatology, University of Oxford, UK.

Keywords

Thymus Gland, B-Lymphocytes, Killer Cells, Natural, T-Lymphocytes, Hematopoietic Stem Cells, Animals, Humans, Apoptosis, Cell Differentiation, Immunologic Memory, Gene Expression Regulation, Energy Metabolism, Homeostasis, Autophagy, Autophagy-Related Protein 5, Autophagy-Related Protein 7