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Increased failure rates due to metallic wear particle-associated adverse local tissue reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty. Retrieved periprosthetic tissue of 53 cases with corrosion/conventional metallic wear particles from 285 revision operations for ALTR was selected for nano-analyses. Three major classes of hip implants associated with ALTR, metal-on-metal hip resurfacing arthroplasty (MoM HRA) and large head total hip replacement (MoM LHTHA) and non-metal-on-metal dual modular neck total hip replacement (Non-MoM DMNTHA) were included. The size, shape, distribution, element composition, and crystal structure of the metal particles were analyzed by conventional histological examination and electron microscopy with analytic tools of 2D X-ray energy dispersive spectrometry and X-ray diffraction. Distinct differences in size, shape, and element composition of the metallic particles were detected in each implant class which correlate with the histological features of severity of ALTR and variability in implant performance.

Original publication




Journal article



Publication Date





1205 - 1217


Adverse local tissue reaction (ALTR), Hip arthroplasty, Metal-on-metal hip resurfacing arthroplasty (MoM HRA), Metal-on-metal large head total hip replacement (MoM LHTHA), Non-metal-on-metal dual modular neck total hip replacement (non-MoM DMNTHA), Arthroplasty, Replacement, Hip, Corrosion, Female, Hip Prosthesis, Humans, Male, Metals, Middle Aged, Nanoparticles, Prosthesis Design, Prosthesis Failure