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A number of previous studies have reported a potential risk of malignancy, particularly hematological malignancy, developing in patients receiving a metal-on-metal (MoM) hip replacement. We report a case of malignant lymphoma that arose in a patient who had an MoM hip arthroplasty complicated by development of a pseudotumour. The tumour was a B cell follicular lymphoma that involved lymph nodes and bone. Metal ions are known to have a genotoxic effect on lymphoid cells. Although epidemiological studies have not established that there is an increased risk of lymphoma associated with MoM implants, only a relatively short time period has elapsed since re-introduction of this type of implant and long-term follow-up of patients with MoM implants is indicated.

Original publication

DOI

10.1007/s00256-017-2612-y

Type

Journal article

Journal

Skeletal radiology

Publication Date

06/2017

Volume

46

Pages

831 - 836

Addresses

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3, 7HE, UK.

Keywords

Hip Joint, Humans, Lymphoma, Follicular, Magnetic Resonance Imaging, Radiography, Ultrasonography, Arthroplasty, Replacement, Hip, Prosthesis Design, Hip Prosthesis, Middle Aged, Female, Metal-on-Metal Joint Prostheses