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The incidence of Perthes disease varies markedly both between countries and within countries down to a local level. The disease is more common in white than in Asian or black African children. The disease is associated with deprivation; with a steep disease gradient across social class groups. This epidemiology alongside the lack of concordance in twins suggests a strong environmental etiology, with little evidence to suggest a genetic predisposition. Children are frequently short, with a growth pattern described as "rostral-sparing". A propensity to associated congenital anomalies suggests an intrauterine cause.

Original publication

DOI

10.1016/j.ocl.2011.03.002

Type

Journal article

Journal

The Orthopedic clinics of North America

Publication Date

07/2011

Volume

42

Pages

279 - v

Addresses

Department of Child Health, University of Liverpool, Liverpool, UK. danperry@doctors.org.uk

Keywords

Humans, Morbidity, Incidence, Risk Factors, Environmental Exposure, World Health, Legg-Calve-Perthes Disease