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The incidence of Perthes disease varies markedly both between countries and within countries down to a local level. The disease is more common in white than in Asian or black African children. The disease is associated with deprivation; with a steep disease gradient across social class groups. This epidemiology alongside the lack of concordance in twins suggests a strong environmental etiology, with little evidence to suggest a genetic predisposition. Children are frequently short, with a growth pattern described as "rostral-sparing". A propensity to associated congenital anomalies suggests an intrauterine cause.

Original publication




Journal article


Orthop clin north am

Publication Date





279 - v


Environmental Exposure, Global Health, Humans, Incidence, Legg-Calve-Perthes Disease, Morbidity, Risk Factors