Arnon Group | Humoral Immune Response
The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.
The spleen is unique from other lymphoid organs in its ability to filter blood antigens. Its large size and highly vascularised nature makes it a central hub for lymphocyte trafficking, cell-cell interactions and information exchange.
Dysfunction of the spleen is associated with increased incident of sepsis due to uncontrolled bacterial infections, failure of peripheral tolerance and enhanced proliferation of myeloid cells with pathological potential. However, despite its importance, the spleen remains largely unexplored and little is known about the nature of cellular movement and interactions within this unique environment.
Our lab focuses on understanding the spatiotemporal organisation of splenic immune responses and the way by which migrating B cells interact with other resident cell types in vivo to achieve an efficient and balanced immune response.
To address these questions and to investigate both molecular and dynamic aspects of B cell behaviour in real-time, we use a combination of approaches including the development of novel mouse models and application of advanced intravital imaging techniques.
Our long-term goals are to understand how dis-regulation of B cell activation during homeostatic or immunological challenges can lead to chronic inflammation and disease.