Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

We aim to identify the mechanisms contributing to bone disease caused by cancer and develop new treatments for these conditions.

A group photo of the Edwards Group | Bone Oncology team

Metastasis of cancers to bone

Cancer-induced bone disease is a characteristic feature of several types of cancer, including the hematological malignancy multiple myeloma, and other tumors that metastasise to bone such as breast, prostate and lung. In addition to the development of debilitating skeletal complications, the bone marrow provides a unique hospitable microenvironment, and once tumors become established in bone, they are largely unresponsive to treatment.

The overall goal of our research is to elucidate the cellular and molecular mechanisms that contribute to disease pathogenesis, and so identify and validate novel therapeutic approaches. Our focus is on the role of the tumor microenvironment and tumor-host interactions.

Major ThemeS

  • Obesity, adipocytes and adipokines in tumour growth and cancer-induced bone disease
  • Aging, senescence and dormancy in the tumour-bone microenvironment
  • Metabolism in the prostate cancer-bone microenvironment
  • Using microfluidics to study the tumour-bone microenvironment
  • Circulating tumour cells in prostate cancer bone metastasis

Related research themes