Surgical Intervention Trials Unit
SITU announces a trio of new trials
SITU-NDORMS has announced the launch of three major new clinical trials. Funded by the NIHR, these studies are providing evidence for the treatment of chronic low back pain, knee osteoarthritis, and ACL injuries.
Read moreWELCOME TO THE SURGICAL INTERVENTION TRIALS UNIT (SITU NDORMS)
SITU is one of eight Royal College of Surgeons of England specialist trials centres dedicated to evaluating surgical intervention, mainly by generating randomised control trial evidence. We are a multidisciplinary team who provide, guidance, training and support for the development of new surgical trials and future trialists. We draw upon the considerable methodological and practical trials expertise in Oxford including statistical, ethical, health economic, systematic review, clinical network resources and the IDEAL collaboration.
Currently, less than 5% of government funding for medical research goes into surgery
ABOUT
We are a centre of excellence in surgical trials, answering important global surgical questions.
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Read about our research and collaborations in the medical and healthcare research community.
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Meet our multidisciplinary team of worldwide experts in surgical trials.
Latest news
SITU announces a trio of new trials
18 June 2024
SITU-NDORMS has announced the launch of three major new clinical trials. Funded by the NIHR, these studies are providing evidence for the treatment of chronic low back pain, knee osteoarthritis, and ACL injuries.
Success for NDORMS at the Vice Chancellor’s Awards
10 May 2024
Dr Anjali Shah from the Botnar Institute won the Research Culture Award, and the Kennedy Histology Team won the Community Partnership Award.
Justin Wormald wins NIHR awards and takes up position as SITU Deputy Director
17 April 2024
NDORMS alumnus Justin Wormald has been awarded an NIHR Academic Clinical Lectureship and an NIHR Development and Skills Enhancement (DSE) Award, as well as being appointed as Deputy Director of the Surgical Trials Intervention Unit (SITU-NDORMS).
The UNDER Study opens to recruitment
12 April 2024
ROBUST Study Opens to Recruitment
5 January 2024
SpInOuT-F Study Published
22 August 2023
Selected publications
Comparison of surgical or non-surgical management for non-acute anterior cruciate ligament injury: the ACL SNNAP RCT.
Beard DJ. et al, (2024), Health technol assess, 28, 1 - 97
Cost-effectiveness analysis of a pragmatic randomized trial evaluating surgical reconstruction versus rehabilitation in patients with long-standing anterior cruciate ligament injury.
Leal J. et al, (2024), Bone joint j, 106-B, 38 - 45
Effectiveness of nail bed repair in children with or without replacing the fingernail: NINJA multicentre randomized clinical trial.
Jain A. et al, (2023), Br j surg, 110, 432 - 438
Item response theory may account for unequal item weighting and individual-level measurement error in trials that use PROMs: a psychometric sensitivity analysis of the TOPKAT trial.
Harrison CJ. et al, (2023), J clin epidemiol, 158, 62 - 69
Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.
Beard DJ. et al, (2022), Lancet, 400, 605 - 615
Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop.
Beard DJ. et al, (2021), Health technol assess, 25, 1 - 52
Considerations and Methods for Placebo Controls in Surgical Trials: State of the Art Review and ASPIRE Guidance
BEARD DJ. et al, (2019), The lancet
