Contact information
Colleges
Akira Wiberg
BA BM BCh DPhil FRCS(Plast)
Senior Clinical Research Fellow
- Consultant Peripheral Nerve Surgeon
- Principal Investigator, Peripheral Nerve Research Lab
- Arthritis UK Career Development Fellow
Peripheral nerve compression, injury, and pain
I studied medicine at Merton College, Oxford, where I was elected a Postmaster (senior scholar) and awarded the Martin Wronker Prize for taking the Top First in the University’s Medical Sciences BA. After qualifying as a doctor, I undertook the Academic Foundation Programme in Oxford, Core Surgical Training in London, and plastic and reconstructive surgery training in the South West Deanery, followed by an NIHR Clinical Lectureship in Oxford. I then completed a post-CCT Fellowship in peripheral nerve surgery at the Royal National Orthopaedic Hospital and the Cleveland Clinic, London.
From 2016 to 2019, I held an MRC Clinical Research Training Fellowship and completed a DPhil at NDORMS on the genetic architecture of carpal tunnel syndrome (CTS), which laid the foundation for my current translational research in nerve compression and injury.
As a surgeon-scientist, I divide my time between the operating theatre and the laboratory. I am a Consultant Peripheral Nerve Surgeon with the South West Brachial Plexus Team in Bristol, where my practice focuses on reconstructive surgery for brachial plexus and peripheral nerve injuries, and the surgical management of neuropathic pain, including thoracic outlet syndrome.
In Oxford I hold an Arthritis UK Career Development Fellowship and lead the Peripheral Nerve Research Lab at NDORMS. Our group integrates genomics, cell biology, and experimental medicine to improve outcomes for patients with nerve compression injuries and pain, with research programmes focused on:
▪ Mechanisms of CTS and related compression neuropathies, particularly fibrotic and inflammatory changes in peri-neural connective tissue and their relation to pain phenotype.
▪ Polygenic risk scores for risk stratification and phenotyping in compression neuropathies.
▪ Developing gene- and cell-targeted therapies for nerve compression.
▪ Electrical peripheral nerve stimulation to enhance nerve regeneration.
▪ Elucidating the role of peripheral nerve compression in migraine and chronic headache.
I currently co-supervise three DPhil students and one MSc student, and serve as Stipendiary Lecturer in Human Anatomy at Merton College, where I teach first-year medical students.
Key publications
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A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.
Journal article
Wiberg A. et al, (2019), Nat commun, 10
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The Molecular Signature of Neuropathic Pain in a Human Model System
Preprint
Sandy-Hindmarch OP. et al, (2024)
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Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study.
Journal article
Patel B. et al, (2022), Lancet rheumatol, 4, e556 - e565
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Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics.
Journal article
Wiberg A. et al, (2019), Brain, 142, 2938 - 2947
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Systemic inflammatory markers in neuropathic pain, nerve injury and recovery.
Journal article
Sandy-Hindmarch O. et al, (2021), Pain
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Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
Journal article
Zhu L. et al, (2022), Sci transl med, 14
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A Review of Common Hand Conditions.
Journal article
Wiberg A. et al, (2022), Jama, 328, 1771 - 1772
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Genetic correlations between migraine and carpal tunnel syndrome.
Journal article
Wiberg A. et al, (2023), Plast reconstr surg
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T2-weighted MRI defines critical compression in the distal carpal tunnel that is relieved after decompressive surgery.
Journal article
Tullie S. et al, (2022), J plast reconstr aesthet surg
Recent publications
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Time to recovery following open and endoscopic carpal tunnel decompression: meta-analysis.
Journal article
Hartrick OJ. et al, (2025), Bjs open, 9
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Systemic low-grade inflammatory markers are associated with proximal spread of neuropathic symptoms
Journal article
Zvonickova K. et al, (2024), Journal of pain, 25
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Systemic low-grade C-reactive protein is associated with proximal symptom spread in carpal tunnel syndrome
Journal article
Zvonickova K. et al, (2024), Pain reports
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Modifiable Risk Factors for Prevention in Dupuytren Disease: A UK Biobank Case-Control Study.
Journal article
Kang Y. et al, (2024), Plast reconstr surg, 153, 363e - 372e
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The Molecular Signature of Neuropathic Pain in a Human Model System
Preprint
Sandy-Hindmarch OP. et al, (2024)
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Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.
Journal article
Lovegrove CE. et al, (2023), J am soc nephrol
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Genetic correlations between migraine and carpal tunnel syndrome.
Journal article
Wiberg A. et al, (2023), Plast reconstr surg
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Dupuytren's disease is a work-related disorder: results of a population-based cohort study.
Journal article
van den Berge BA. et al, (2023), Occup environ med
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Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
Journal article
Zhu L. et al, (2022), Sci transl med, 14
-
A Review of Common Hand Conditions.
Journal article
Wiberg A. et al, (2022), Jama, 328, 1771 - 1772