Dani Prieto-Alhambra

MD MSc(Oxf) PhD

Professor of Pharmaco- and Device Epidemiology

Section Head, Health Data Sciences, Botnar Research Centre
NIHR Senior Research Fellow
Fellow of the International Society of Pharmaco-Epidemiology, FISPE

Real World Evidence, Pharmaco-epidemiology, Device Epidemiology

I am an epidemiologist and academic clinician scientist using routinely collected (real world) health data to generate reliable evidence for improved patient care.

Through an NIHR Senior Research Fellowship, I am investigating the use, safety, effectiveness and cost of drugs and devices as used in usual practice conditions and amongst older people with complex health needs.

I lead Pharmaco- and Device Epidemiology research at NDORMS, and have experience designing, analysing and interpreting electronic medical records from around the world. I’ve worked on multiple real world data assets nationally and internationally, and have specialized in network studies using the OMOP Common Data Model.

More recently, I have joined the European Health Data & Evidence Network EHDEN (www.ehden.eu) and the Observational Health Data Sciences and Informatics OHDSI (www.ohdsi.org) in an effort to accelerate and improve the quality of real world evidence internationally.

From February 2022, I am Deputy Director for the European Medicines Agency's Data Analysis and Real World Interrogation Network (DARWIN EU) Coordination Centre, and lead the Development pillar for the generation and/or validation of analytical tools to generate real world evidence for regulatory use.

Key publications

The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study.
Journal article

Bayliss LE. et al, (2017), Lancet, 389, 1424 - 1430
Associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 in nursing homes and healthcare workers in Catalonia: prospective cohort study.
Journal article

Cabezas C. et al, (2021), Bmj, 374
Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis.
Journal article

Li X. et al, (2022), Bmj, 376
Characterising the background incidence rates of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study
Journal article

Li X. et al, (2021), The bmj
Comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with different covid-19 vaccines: international network cohort study from five European countries and the US.
Journal article

Li X. et al, (2022), Bmj, 379
Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis.
Journal article

Morales DR. et al, (2021), Lancet digit health, 3, e98 - e114
Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.
Journal article

Lane JCE. et al, (2020), Lancet rheumatol, 2, e698 - e711
Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study.
Journal article

Burn E. et al, (2022), Lancet infect dis
Association of Tramadol vs Codeine Prescriptions With Mortality and Other Adverse Clinical Outcomes-Reply.
Journal article

Xie J. et al, (2022), Jama, 327, 489 - 490
Clinical and Genetic Risk Factors for Acute Incident Venous Thromboembolism in Ambulatory Patients With COVID-19.
Journal article

Xie J. et al, (2022), Jama intern med

Recent publications

Incidence, prevalence, and survival of head and neck cancers in the United Kingdom from 2000-2021
Preprint

Miquel Dominguez A. et al, (2024)
Cardinality matching versus propensity score matching for addressing cluster-level residual confounding in implantable medical device and surgical epidemiology: a parametric and plasmode simulation study.
Journal article

Du M. et al, (2024), Bmc med res methodol, 24
PDE5 inhibition and Alzheimer’s disease risk: a mendelian randomisation study
Preprint

Alcalde-Herraiz M. et al, (2024)
Effect of genetically predicted sclerostin on cardiovascular biomarkers, risk factors, and disease outcomes.
Journal article

Alcalde-Herraiz M. et al, (2024), Nat commun, 15
Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data
Journal article

Xie J. et al, (2024), Eclinicalmedicine, 77, 102903 - 102903
Standardised and Reproducible Phenotyping Using Distributed Analytics and Tools in the Data Analysis and Real World Interrogation Network (DARWIN EU).
Journal article

Dernie F. et al, (2024), Pharmacoepidemiol drug saf, 33
Evaluation of post-acute COVID-19 health outcomes (ECHOES) in England: The development of national surveillance system for long- term health outcomes following COVID-19
Preprint

Allen H. et al, (2024)
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank
Journal article

Alcalde-Herraiz M. et al, (2024), Nature communications, 15
Time Series Methods to Assess the Impact of Regulatory Action: A Study of UK Primary Care and Hospital Data on the Use of Fluoroquinolones.
Journal article

Guo Y. et al, (2024), Pharmacoepidemiol drug saf, 33
Development of a Canadian Guidance for Reporting Real-world Evidence for Regulatory and Health-Technology Assessment (HTA) Decision Making.
Journal article

Tadrous M. et al, (2024), J clin epidemiol

More publications

Cookies on this website

Contact information

Research groups

Websites

Dani Prieto-Alhambra

Key publications

Recent publications