Our Mission

We aim to inform healthcare decisions that improve patient outcomes while optimising the use of limited resources in the UK and internationally, by combining economic evaluation, real‑world data, and outcomes research.

Core Methodological Pillars

• Economic Evaluation: Assessing the cost‑effectiveness of healthcare interventions using decision‑analytic models informed by real‑world data.
• Real‑World Evidence (RWE): Analysing observational and routinely collected data, including datasets mapped to the Common Data Model, to evaluate effectiveness in practice.
• Outcomes Research: Measuring clinical outcomes, quality of life, and patient‑reported outcomes to understand impact on patients and carers.

Application Domains

We apply our methods across many different healthcare conditions and interventions, with particular expertise in musculoskeletal health:

• Osteoporosis & Fracture Prevention: Risk assessment, prevention strategies, and evaluation of services such as fracture liaison programmes.
• Osteoarthritis: Long‑term evaluation of medical and surgical care, including patient‑reported outcomes and decision‑support tools.
• Rare Diseases: Assessing clinical, quality‑of‑life, and economic impact of rare musculoskeletal conditions on patients and healthcare systems.

Data

Our research is grounded in large‑scale real‑world datasets that reflect routine clinical practice, including:

• Electronic health records (e.g. HES, CPRD, SIDIAP)
• Common Data Models (e.g. OMOP)
• National and international registries (e.g. NJR, Geneva Arthroplasty Registry)
• Observational cohorts and disease studies (RUDY)
• Clinical trial data with long‑term follow‑up

Collaborations, Partnerships and Funding

We collaborate with academic institutions, healthcare providers, policymakers, charities, and industry partners.

Our work is supported by organisations such as NIHR, the European Commission, the International Osteoporosis Foundation, and patient charities. Patient and Public Involvement is central to our research, ensuring it remains patient‑centred and grounded in lived experience.