Programme
The workshop will start with a reception followed by a Saturday evening keynote session with talks by Cosima Baldari and Art Weiss. Baldari pioneered work on intraflagellar transport in the immunological synapse and direct impact of the SARS CoV2 spike protein on T cell activation. Weiss’ early work on calcium signalling and ZAP-70 helped establish the field. He will present new data on the mechanism of a pH dependent checkpoint in TCR signalling. They will both discuss their experiences with shaping the culture of the field over the past 30 years.
The science sessions will start on Monday morning. The program from 2022 was highly praised in the evaluations so we have followed some same scheme progression from antigen receptor structure (Session 1), biophysics (Session 2), T-cell receptor (Session 3) and B-cell receptor (Session 4) signalling, vesicular traffic at the immune synapse (Session 5), immunometabolism (Session 6), lymphocyte differentiation (Session 7), immunopathology (Session 8) and immunotherapy (Session 9).
Systems immunology was highlighted in the evaluations as an important area so we have invited Gregoire Altan-Bonnet in response to this suggestion. After the first poster session, day 2 will end on a special interdisciplinary lecture by Chiara Romagnani, an expert in innate memory.
We will also have two special talks on "Speaking to the public" by Anne Spurkland who educated Norwegians on Covid-19, and the "Future of scientific publishing" by Bernd Pulverer, one of the founders of DORA. Posters are up for the entire meeting as there is plenty of space under the cloisters to generate discussion at any time during the meeting.
Ample time has been allotted to networking (coffee breaks, meet-the-scientist sessions, social events).
| Time | Speaker name and topic of talk |
| 14:00-18:30 | Registrations |
| 18:30 | Welcome cocktail |
| 19:00 | Dinner |
| 20:30-20:45 |
Welcome remarks by Mike Dustin |
| 20:45-21:30 | Cosima Baldari, "Lymphocyte antigen receptor signalling- it’s all about getting together" |
| 21:30-22:15 | Arthur Weiss, “Calcium fluxes to pH-dependent checkpoints- never-ending wonders of antigen receptor signalling. |
| Time | Speaker name and topic of talk |
| 7:30-9:00 | Breakfast |
| 9:00-10:45 |
Structural basis of antigen recognition Chair - C. Xu |
| 9:00-9:20 | Robert Tampé, “Structural insights into antigen recognition by the TCR” |
| 9:20-9:30 |
Maximilian Zehetmaier, "Engineered signaling-primed T cell receptors for structural and mechanistic analyses" |
| 9:30-9:45 | Michelle Krogsgaard, "Intramolecular dynamics of TCR" |
| 9:45-10:00 | Santosh Kumar, "Cytoplasmic domains of inhibitory receptors" |
| 10:00-10:15 |
Floris van Eerden, "TCR-pMHC complex formation triggers CD3 dynamics" |
| 10:15-10:33 | Chenqi Xu, “Dynamics of antigen receptor tails” |
| 10:35-10:45 |
Zhengxu Ren, "Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity" |
| 10:45-11:15 | Coffee break |
| 11:15-13:00 |
Biophysics of antigen receptor signalling Chair - Marco Fritzsche |
| 11:15-11:45 | Eva Savcsik, "Signaling from Single TCRs" |
| 11:45-12:00 |
Franziska Ragaller, "The biophysical landscape of reconstituted immune synapses" |
| 12:00-12:15 |
Cheng Zhu, "Mechanotransduction through immunoreceptors" |
| 12:15-12:45 | Peter Jonsson, “2D affinity at membrane interfaces” |
| 12:45-13:00 | Mike Dustin, “Bispecific T cell engagers mind the gap” |
| 13:00-14:30 | Lunch and meet-the-speaker tables |
| 14:30-15:00 |
Annemiek Van Spriel, "Role of tetraspanin domains in TCR signalling" |
| 15:00-15:30 |
Gregoire Altan-Bonnet, "Engineering CAR-T cell specificity, using robotic dynamic profiling & machine learning" |
| 15:30-15:45 |
Susana Minguet, "Bidirectional learning: TCRs and CARs" |
| 15:45-16:00 |
Jose Cabezas Caballero, "Genetically engineering T cells to reduce risk of autoimmune cross-reactivities in T cell therapies" |
| 16:00-16:45 |
CIBSS Special Lecture by Chiara Romangnani (Introduced by Wolfgang Schamel of CIBSS), "Innate memory in NK cell response to chronic infection" |
| 17:00-19:00 |
Posters Odd poster numbers |
| 19:00 | Dinner |
| Time | Speaker name and topic of talk |
| 7:30-9:00 | Breakfast |
| 9:00-10:30 |
BCR signaling Chair - J. Wienands |
| 9:00-9:30 | David Tarlinton, "B cell memory, IgE and allergy" |
| 9:30-9:45 |
Anna-Maria Schaffer, "Kidins220 regulates the development of B cells bearing the λ light chain" |
| 9:45-10:15 | Bebhinn Treanor, "Signalling for better neutralizing antibodies" |
| 10:15-10:30 | Jürgen Wienands, "Primary and secondary B cell fate decisions" |
| 10:30-11:00 | Coffee break |
| 11:00-12:30 |
Building the Immunological Synapse Chair - Hivroz |
| 11:00-11:15 |
Claire Hivroz, "PD-1 effects on the formation of the immunological synapse" |
| 11:15-11:30 |
Srishtri Mandal, "Mechanosensing and perturbation at the T cell immunological synapse" |
| 11:30-11:45 |
Amna Music, "Lysosomes in early B cell activation" |
| 11:45-12:15 | Katelyn Spillane, “Role of mechanical force in antigen capture” |
| 12:15-12:30 | Anne Spurkland, “Talking to the public about signaling” |
| 12:30-12:45 | Bernd Pulverer, “The Future of Scientific Publishing” |
| 12:45-13:00 |
Discussion on scientific communication led by Anne and Bernd |
| 13:00-14:30 | Lunch and meet-the-speaker tables |
| 14:30-16:00 |
Immunometabolism Chair - Katja Simon |
| 14:30-15:00 | Katja Simon, "Autophagy and aging" |
| 15:00-15:15 |
Alessio Lanna, "Discoveries of new rejuvenating interventions" |
| 15:15-15:30 |
Mariana Borsa, "Autophagy and asymmetric cell division" |
| 15:30-16:00 | Maria Mittelbrunn, “Immunometabolism and rejuvenation” |
| 16:15 |
Shuttle to Siena, guided tour, dinner at Contrada della Tartuca |
| Time | Speaker name and topic of talk |
| 7:30-9:00 | Breakfast |
| 9:00-10:30 |
Signaling in lymphocyte differentiation Chair - C Vinuesa |
| 9:00-9:15 | Wolfgang Schamel, "Optogenetic control of T cell differentiation" |
| 9:15-9:30 |
Anna Ehert, "Optogenetic TCR Control Reveals Differential Pathway Dynamics in T Cell Activation and Has Implications for Immunomodulation" |
| 9:30-9:45 | Yolanda Carrasco, "CD40 signalling in B cell differentiation" |
| 9:45-10:00 |
Ondřej Štěpánek, “Role of co-receptors in T-cell development” |
| 10:00-10:30 | Carola Vinuesa, “Integration of novel signals with antigen recognition” |
| 10:30-11:00 | Coffee break |
| 11:00-13:00 |
Immunity and Immunopathology Chair – de la Rosa |
| 11:00-11:30 | Pierre Bruhns, "IgE BCR, memory and allergy" |
| 11:30-12:00 | Pavel Tolar, "BCR signalling in lymphoma" |
| 12:00-12:15 |
Margot Thome, "Update on PD1 signalling" |
| 12:15-12:30 |
Farah Mustapha, "Nef decreases membrane tension in HIV-infected CD4+ T cells as a mechanism of CTL evasion" |
| 12:30-13:00 | Katrin de la Rosa, “BCR diversification and selection in infection” |
| 13:00-14:30 | Lunch and meet-the-speaker tables |
| 14:30-17:00 |
Translating antigen receptor signaling Chair - Thome |
| 14:30-15:00 | Michael Milone, "KIR CARs Stand up to TME" |
| 15:00-15:15 |
Janelle Waite, "Bispecific engagers recruiting co-stimulation"
|
| 15:15-15:30 |
Carmen Ramirez, "Clustering of signaling molecules is driven by microvilli architecture in CAR- and TCR-mediated T cell activation" |
| 15:30-15:45 |
Benita Wolf, "Cryo-Expansion Microscopy to Unveil the Nanoscale Architecture of Engineered Immune Synapses" |
| 15:45-16:45 |
Balbino Alarcon, "Targeting TCR conformational change" |
| 17:00-19:00 |
Posters Even number posters |
| 19:00-19:20 |
Nature Poster Prize and EMBO ECR Short Talk Prize, concluding remarks, open discussion about next conference |
| 19:30 | Banquet |
| 22:00 | Dance party |