Programme
The workshop will start with a reception followed by a Saturday evening keynote session with talks by Cosima Baldari and Art Weiss. Baldari pioneered work on intraflagellar transport in the immunological synapse and direct impact of the SARS CoV2 spike protein on T cell activation. Weiss’ early work on calcium signalling and ZAP-70 helped establish the field. He will present new data on the mechanism of a pH dependent checkpoint in TCR signalling. They will both discuss their experiences with shaping the culture of the field over the past 30 years.
The science sessions will start on Monday morning. The program from 2022 was highly praised in the evaluations so we have followed some same scheme progression from antigen receptor structure (Session 1), biophysics (Session 2), T-cell receptor (Session 3) and B-cell receptor (Session 4) signalling, vesicular traffic at the immune synapse (Session 5), immunometabolism (Session 6), lymphocyte differentiation (Session 7), immunopathology (Session 8) and immunotherapy (Session 9).
Systems immunology was highlighted in the evaluations as an important area so we have invited Gregoire Altan-Bonnet in response to this suggestion. After the first poster session, day 2 will end on a special interdisciplinary lecture by Chiara Romagnani, an expert in innate memory.
We will also have two special talks on "Speaking to the public" by Anne Spurkland who educated Norwegians on Covid-19, and the "Future of scientific publishing" by Bernd Pulverer, one of the founders of DORA. Poster presenters will lead off the two dedicated poster sessions with lightning talks to gain valuable public speaking experience. Posters are up for the entire meeting as there is plenty of space under the cloisters to generate discussion at any time during the meeting.
Ample time has been allotted to networking (coffee breaks, meet-the-scientist sessions, social events).
Time | Programme category | Speaker name and topic of talk |
14:00-18:30 | REGISTRATIONS | |
18:30 | WELCOME COCKTAIL | |
19:00 | DINNER | |
20:30-20:45 | KEYNOTE SESSION |
Welcome remarks by Mike Dustin, UK |
20:45-21:30 | KEYNOTE 1 | Cosima Baldari "Lymphocyte antigen receptor signalling- it’s all about getting together" |
21:30-22:15 | KEYNOTE 2 | Arthur Weiss “Calcium fluxes to pH-dependent checkpoints- never-ending wonders of antigen receptor signalling. |
Time | Programme category | Speaker name and topic of talk |
7:30-9:00 | BREAKFAST | |
9:00-10:45 | SESSION 1 | Structural basis of antigen recognition - Chair - C. Xu |
9:00-9:20 | TALK 1 | Robert Tampé “Structural insights into antigen recognition by the TCR” |
9:20-9:30 | SHORT TALK 1 |
Maximilian Zehetmaier, "Engineered signaling-primed T cell receptors for structural and mechanistic analyses" |
9:30-9:45 | SHORT TALK 2 | Michelle Krogsgaard "Intramolecular dynamics of TCR" |
9:45-10:00 | TALK 2 | Santosh Kumar "Cytoplasmic domains of inhibitory receptors" |
10:00-10:15 | SHORT TALK 3 |
Floris van Eerden, "TCR-pMHC complex formation triggers CD3 dynamics" |
10:15-10:33 | TALK 3 | Chenqi Xu, “Dynamics of antigen receptor tails” |
10:35-10:45 | TALK 4 |
Zhengxu Ren, "Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity" |
10:45-11:15 | COFFEE BREAK | |
11:15-13:00 | SESSION 2 | Biophysics of antigen receptor signalling Chair - Marco Fritzsche |
11:15-11:45 | TALK 4 | Eva Savcsik "Signaling from Single TCRs" |
11:45-12:00 | SHORT TALKS 3 |
Franziska Ragaller, "The biophysical landscape of reconstituted immune synapses" |
12:00-12:15 | SHORT TALK 4 |
Cheng Zhu, "Mechanotransduction through immunoreceptors" |
12:15-12:45 | TALK 5 | Peter Jonsson “2D affinity at membrane interfaces” |
12:45-13:00 | SHORT TALK 5 | Mike Dustin “Bispecific T cell engagers mind the gap” |
13:00-14:30 | LUNCH | Meet-the-speaker tables |
14:30-15:00 | FLASH TALK 1 |
Annemiek Van Spriel, "Role of tetraspanin domains in TCR signalling" |
15:00-15:30 | FLASH TALK 2 |
Gregoire Altan-Bonnet, "Engineering CAR-T cell specificity, using robotic dynamic profiling & machine learning" |
15:30-15:45 | FLASH TALK 3 |
Susana Minguet, "Bidirectional learning: TCRs and CARs" |
15:45-16:00 | FLASH TALK 4 |
Jose Cabezas Caballero, "Genetically engineering T cells to reduce risk of autoimmune cross-reactivities in T cell therapies" |
16:00-16:45 | TALK 6 |
CIBSS Special Lecture by Chiara Romangnani (Introduced by Wolfgang Schamel of CIBSS), "Innate memory in NK cell response to chronic infection" |
17:00-19:00 | POSTERS 1 | Odd Poster numbers |
19:00 | DINNER |
Time | Programme Category | Speaker name and topic of talk |
7:30-9:00 | BREAKFAST | |
9:00-10:30 | SESSION 4 | BCR signaling- Chair - J. Wienands |
9:00-9:30 | TALK 8 | David Tarlinton "B cell memory, IgE and allergy" |
9:30-9:45 | SHORT TALK 7 | 1 selected from abstracts |
9:45-10:15 | TALK 9 | Bebhinn Treanor "Signalling for better neutralizing antibodies" |
10:15-10:30 | SHORT TALK 8 | Jürgen Wienands "Primary and secondary B cell fate decisions" |
10:30-11:15 | COFFEE BREAK | |
11:15-12:30 | SESSION 5 | Building the Immunological Synapse Chair - Hivroz |
11:15-11:30 | SHORT TALK 9 | Claire Hivroz "Receptor trafficking" |
11:30-11:45 | SHORT TALK 10 | 1 selected from abstracts |
11:45-12:00 | SHORT TALK 11 | 1 selected from abstracts |
12:00-12:30 | TALK 10 | Katelyn Spillane “Role of mechanical force in antigen capture” |
12:30-12:45 | SPECIAL TALK 2 | Anne Spurkland “Talking to the public about signaling” |
12:45-13:00 | SPECIAL TALK 3 | Bernd Pulverer “The Future of Scientific Publishing” |
13:00-15:00 | LUNCH | Meet-the-speaker tables |
15:00-16:15 | SESSION 6 | Immunometabolism Chair - Simon |
15:00-15:30 | TALK 11 | Katja Simon "Autophagy and aging" |
15:30-15:45 | SHORT TALK 12 | 1 selected from abstracts |
15:45-16:15 | TALK 12 | Maria Mittelbrunn “Immunometabolism and rejuvenation” |
16:30 | SIENA TRIP | Shuttle to Siena, guided tour, dinner at local restaurant |
Time | Programme category | Speaker name and topic of talk |
7:30-9:00 | BREAKFAST | |
9:00-10:30 | SESSION 7 | Signaling in lymphocyte differentiation Chair - C Vinuesa |
9:00-9:30 | TALK 13 | Wolfgang Schamel "Optogenetic control of T cell differentiation" |
9:30-9:45 | SHORT TALK 13 | Yolanda Carrasco "CD40 signalling in B cell differentiation" |
9:45-10:00 | SHORT TALK 14 |
Ondřej Štěpánek “Role of co-receptors in T-cell development” |
10:00-10:30 | TALK 14 | Carola Vinuesa “Integration of novel signals with antigen recognition” |
10:30-11:00 | COFFEE BREAK | |
11:00-13:00 | SESSION 8 | Immunity and Immunopathology Chair – de la Rosa |
11:00-11:30 | TALK 15 | Pierre Bruhns "IgE BCR, memory and allergy" |
11:30-12:00 | TALK 16 | Pavel Tolar "BCR signalling in lymphoma" |
12:00-12:30 | SHORT TALKS 15 AND 16 | 2 selected from abstracts |
12:30-13:00 | TALK 17 | Katrin de la Rosa “BCR diversification and selection in infection” |
13:00-14:30 | LUNCH | Meet-the-speaker tables |
14:30-15:00 | FLASH TALKS 2 | Even poster numbers |
15:00-17:30 | POSTER SESSION 2 | Even poster numbers |
17:30-19:00 | SESSION 9 | Translating antigen receptor signaling Chair - Thome |
17:30-18:00 | TALK 18 | Michael Milone "KIR CARs Stand up to TME" |
18:00-18:15 | SHORT TALK 18 | Margot Thome “Update on PD1 signaling” |
18:15-18:30 | SHORT TALK 19 | 1 selected from abstracts |
18:30-19:00 | TALK 19 | Balbino Alarcon “Targeting TCR conformational change” |
19:00-19:15 | CLOSING DISCUSSION | Awards ceremony and panel discussion with organizers on future plans for the workshop |
19:30 | BANQUET | |
22:00 | DANCE PARTY |