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We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

Original publication

DOI

10.3109/17453679808999060

Type

Journal article

Journal

Acta orthopaedica Scandinavica

Publication Date

08/1998

Volume

69

Pages

420 - 425

Addresses

Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, U.K. gang.li@orthopaedic-surgery.ox.ac.uk

Keywords

Tibia, Osteoblasts, Animals, Rabbits, Humans, Disease Models, Animal, Bone Morphogenetic Proteins, RNA, Messenger, Osteogenesis, Distraction, Blotting, Northern, In Situ Hybridization, Bone Regeneration, Gene Expression, Osteogenesis, Bone Morphogenetic Protein 4