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A through-knee amputation for suspected osteogenic sarcoma was performed on a patient with Paget's disease of the tibia. Plasma alkaline phosphatase (AP) activity fell to normal values, apparently as a single exponential function of time, with a half-life of 1.7 days. The daily turnover of bone-derived plasma AP was estimated to be approximately 200 I.U. from the Pagetic tibia and 20 I.U. from the rest of the skeleton.


Journal article


Clinica chimica acta; international journal of clinical chemistry

Publication Date





227 - 229


Bone and Bones, Tibia, Humans, Osteitis Deformans, Alkaline Phosphatase, Half-Life, Middle Aged, Male