Inflammatory arthritis is encompassed by a wide range of multifaceted arthropathies, including Spondyloarthritis (SpA) and Reactive Arthritis. There is a clear gut component in inflammatory arthritis. Patients with SpA commonly present with intestinal inflammation, and some gut microbiota shifts are common between patients with SpA and patients with inflammatory bowel disease..
The Powrie lab aims to identify and characterise the host-microbiota interactions driving systemic inflammation in arthritis using well established experimental models as well as new models that probe causal relationships between the gut microbiome and joint inflammation. This work aims to further our understanding of the role of the intestinal microbiota in systemic disease, and hopes to inform microbiota-based therapeutic strategies for inflammatory arthritis.
1. Exploring the role of the microbiome in reactive arthritis disease pathogenesis